Amylyx Pharmaceuticals, Inc. — Insider Transactions
Form 4 filings by directors, officers, and 10%+ shareholders
SEC rules require corporate insiders — including directors, executive officers, and any shareholder owning more than 10% of a company's shares — to report changes in their ownership within two business days of a transaction. These disclosures are filed as Form 4. Open-market purchases (code P) are generally considered the most meaningful signal, as insiders are spending their own money.
| Insider | Title | Type | Shares | Price | Value | Owns After | Date |
|---|---|---|---|---|---|---|---|
| Firestone Karen | — | Purchase | 8,100 | $12.45 | $100,845 | 63,100 | Dec 23, 2025 |
| Bedrosian Camille L | Chief Medical Officer | Sale | 6,580 | $14.35 | $94,423 | 175,756 | Dec 1, 2025 |
| Klee Justin B. | Co-Chief Executive Officer | Sale | 200 | $15.01 | $3,002 | 3,325,301 | Sep 30, 2025 |
| Mazzariello Gina | Chief Legal Officer | Sale | 8,828 | $14.58 | $128,712 | 148,141 | Sep 30, 2025 |
| FRATES JAMES M | Chief Financial Officer | Sale | 10,558 | $14.65 | $154,675 | 280,430 | Sep 30, 2025 |
| Cohen Joshua B | Co-Chief Executive Officer | Sale | 200 | $15.00 | $3,000 | 3,325,347 | Sep 30, 2025 |
| Bedrosian Camille L | Chief Medical Officer | Sale | 12,039 | $14.58 | $175,529 | 182,336 | Sep 30, 2025 |
| Mazzariello Gina | Chief Legal Officer | Sale | 15,000 | $8.07 | $121,050 | 171,969 | Aug 13, 2025 |
| Mazzariello Gina | Chief Legal Officer | Gift | 1,000 | — | — | 186,969 | May 22, 2025 |
| FRATES JAMES M | Chief Financial Officer | Sale | 10,896 | $3.47 | $37,809 | 290,988 | Mar 31, 2025 |
| Bedrosian Camille L | Chief Medical Officer | Sale | 12,425 | $3.47 | $43,115 | 194,375 | Mar 31, 2025 |
| Mazzariello Gina | Chief Legal Officer | Sale | 9,192 | $3.48 | $31,988 | 187,969 | Mar 31, 2025 |
| Cohen Joshua B | Co-Chief Executive Officer | Sale | 21,490 | $3.47 | $74,570 | 3,355,280 | Mar 31, 2025 |
| Klee Justin B. | Co-Chief Executive Officer | Sale | 21,490 | $3.46 | $74,355 | 3,355,276 | Mar 31, 2025 |
| Zeiher Bernhardt G | — | Purchase | 10,000 | $3.70 | $37,000 | 10,000 | Mar 20, 2025 |
| Mazzariello Gina | Chief Legal Officer | Award / Grant | 63,851 | — | — | 197,161 | Mar 6, 2025 |
| Bedrosian Camille L | Chief Medical Officer | Award / Grant | 68,420 | — | — | 206,800 | Mar 6, 2025 |
| Klee Justin B. | Co-Chief Executive Officer | Award / Grant | 180,118 | — | — | 3,376,766 | Mar 6, 2025 |
| Cohen Joshua B | Co-Chief Executive Officer | Award / Grant | 180,118 | — | — | 3,376,770 | Mar 6, 2025 |
| FRATES JAMES M | Chief Financial Officer | Award / Grant | 68,420 | — | — | 301,884 | Mar 6, 2025 |
| Klee Justin B. | Co-Chief Executive Officer | Sale | 4,595 | $3.15 | $14,474 | 3,196,648 | Mar 3, 2025 |
| Cohen Joshua B | Co-Chief Executive Officer | Sale | 4,595 | $3.17 | $14,566 | 3,196,652 | Mar 3, 2025 |
| Mazzariello Gina | Chief Legal Officer | Sale | 1,611 | $3.12 | $5,026 | 133,310 | Mar 3, 2025 |
| Mazzariello Gina | Chief Legal Officer | Sale | 4,169 | $3.15 | $13,132 | 134,921 | Feb 24, 2025 |
| Klee Justin B. | Co-Chief Executive Officer | Option Exercise | 36,310 | $1.57 | $57,007 | 3,201,243 | Feb 5, 2025 |
| Mazzariello Gina | Chief Legal Officer | Sale | 3,678 | $3.49 | $12,836 | 139,090 | Feb 3, 2025 |
| Cohen Joshua B | Co-Chief Executive Officer | Sale | 11,851 | $3.47 | $41,123 | 3,201,247 | Feb 3, 2025 |
| Klee Justin B. | Co-Chief Executive Officer | Sale | 11,855 | $3.47 | $41,137 | 3,164,933 | Feb 3, 2025 |
| MILNE GEORGE M JR | — | Gift | 27,910 | — | — | 830,661 | Jan 24, 2025 |
| Klee Justin B. | Co-Chief Executive Officer | Sale | 7,471 | $4.04 | $30,183 | 3,176,788 | Jan 6, 2025 |
| Cohen Joshua B | Co-Chief Executive Officer | Sale | 7,471 | $4.05 | $30,258 | 3,213,098 | Jan 6, 2025 |
| Bedrosian Camille L | Chief Medical Officer | Sale | 5,421 | $5.54 | $30,032 | 138,380 | Dec 2, 2024 |
| Klee Justin B. | Co-Chief Executive Officer | Option Exercise | 63,690 | $1.57 | $99,993 | 3,184,259 | Nov 4, 2024 |
| Klee Justin B. | Co-Chief Executive Officer | Sale | 18,589 | $3.20 | $59,485 | 3,120,569 | Sep 30, 2024 |
| Cohen Joshua B | Co-Chief Executive Officer | Sale | 18,589 | $3.20 | $59,485 | 3,220,569 | Sep 30, 2024 |
| Bedrosian Camille L | Chief Medical Officer | Sale | 11,442 | $3.20 | $36,614 | 143,801 | Sep 30, 2024 |
| Mazzariello Gina | Chief Legal Officer | Sale | 8,709 | $3.20 | $27,869 | 142,768 | Sep 30, 2024 |
| Cohen Joshua B | Co-Chief Executive Officer | Option Exercise | 1,857 | $1.57 | $2,915 | 3,239,158 | Sep 23, 2024 |
| Cohen Joshua B | Co-Chief Executive Officer | Option Exercise | 34,449 | $1.57 | $54,085 | 3,237,301 | Sep 12, 2024 |
| FRATES JAMES M | Chief Financial Officer | Purchase | 40,000 | $2.53 | $101,200 | 233,464 | Sep 12, 2024 |
| Firestone Karen | — | Purchase | 50,000 | $2.13 | $106,500 | 55,000 | Sep 5, 2024 |
| MILNE GEORGE M JR | — | Purchase | 100,000 | $2.20 | $220,000 | 858,571 | Sep 3, 2024 |
| Mazzariello Gina | Chief Legal Officer | Sale | 10,455 | $1.88 | $19,655 | 151,477 | May 15, 2024 |
| Quimi Daphne | — | Purchase | 2,250 | $1.89 | $4,253 | 5,000 | May 14, 2024 |
| FRATES JAMES M | Chief Financial Officer | Award / Grant | 91,180 | — | — | 225,964 | Apr 16, 2024 |
| Cohen Joshua B | Co-Chief Executive Officer | Award / Grant | 179,850 | — | — | 3,202,852 | Apr 16, 2024 |
| Mazzariello Gina | Chief Legal Officer | Award / Grant | 80,560 | — | — | 161,932 | Apr 16, 2024 |
| Klee Justin B. | Co-Chief Executive Officer | Award / Grant | 179,850 | — | — | 3,139,158 | Apr 16, 2024 |
| Bedrosian Camille L | Chief Medical Officer | Award / Grant | 96,910 | — | — | 155,243 | Apr 16, 2024 |
| Cohen Joshua B | Co-Chief Executive Officer | Sale | 4,135 | $18.73 | $77,449 | 3,023,002 | Mar 5, 2024 |