OPKO HEALTH, INC. — Insider Transactions
Form 4 filings by directors, officers, and 10%+ shareholders
SEC rules require corporate insiders — including directors, executive officers, and any shareholder owning more than 10% of a company's shares — to report changes in their ownership within two business days of a transaction. These disclosures are filed as Form 4. Open-market purchases (code P) are generally considered the most meaningful signal, as insiders are spending their own money.
| Insider | Title | Type | Shares | Price | Value | Owns After | Date |
|---|---|---|---|---|---|---|---|
| Frost Gamma Investments Trust | — | Purchase | 192,870 | $1.34 | $258,446 | 216,706,448 | Nov 21, 2025 |
| Frost Gamma Investments Trust | — | Purchase | 13,664 | $1.35 | $18,446 | 216,126,448 | Nov 20, 2025 |
| Frost Gamma Investments Trust | — | Purchase | 66,504 | $1.31 | $87,120 | 215,192,048 | Nov 19, 2025 |
| Frost Gamma Investments Trust | — | Purchase | 428 | $1.28 | $548 | 214,849,319 | Nov 18, 2025 |
| FROST PHILLIP MD ET AL | CEO & Chairman | Purchase | 150,000 | $1.42 | $213,000 | 214,386,448 | Oct 31, 2025 |
| FROST PHILLIP MD ET AL | CEO & Chairman | Gift | 440,000 | — | — | 214,236,448 | Aug 18, 2025 |
| FROST PHILLIP MD ET AL | CEO & Chairman | Purchase | 675,000 | $1.32 | $891,000 | 214,676,448 | Aug 8, 2025 |
| FROST PHILLIP MD ET AL | CEO & Chairman | Purchase | 125,000 | $1.36 | $170,000 | 214,001,448 | Apr 10, 2025 |
| Frost Gamma Investments Trust | — | Purchase | 125,000 | $1.48 | $185,000 | 213,876,448 | Apr 8, 2025 |
| FROST PHILLIP MD ET AL | CEO & Chairman | Purchase | 100,000 | $1.65 | $165,000 | 213,751,448 | Apr 1, 2025 |
| Frost Gamma Investments Trust | — | Purchase | 150,000 | $1.70 | $255,000 | 213,651,448 | Mar 28, 2025 |
| Frost Gamma Investments Trust | — | Purchase | 200,000 | $1.74 | $348,000 | 213,501,448 | Mar 17, 2025 |
| Frost Gamma Investments Trust | — | Purchase | 67,434 | $1.71 | $115,312 | 213,301,448 | Feb 28, 2025 |
| Frost Gamma Investments Trust | — | Purchase | 47,537 | $1.47 | $69,879 | 213,234,014 | Jan 28, 2025 |
| Frost Gamma Investments Trust | — | Purchase | 150,000 | $1.47 | $220,500 | 213,186,477 | Jan 17, 2025 |
| FROST PHILLIP MD ET AL | CEO & Chairman | Purchase | 500,000 | $1.48 | $740,000 | 213,036,477 | Jan 15, 2025 |
| Frost Gamma Investments Trust | — | Purchase | 125,000 | $1.60 | $200,000 | 212,536,477 | Dec 13, 2024 |
| Frost Gamma Investments Trust | — | Purchase | 500,000 | $1.56 | $780,000 | 212,411,477 | Dec 11, 2024 |
| Frost Gamma Investments Trust | — | Purchase | 199,072 | $1.53 | $304,580 | 211,911,477 | Nov 29, 2024 |
| Frost Gamma Investments Trust | — | Purchase | 100,000 | $1.59 | $159,000 | 211,712,405 | Nov 22, 2024 |
| FROST PHILLIP MD ET AL | CEO & Chairman | Purchase | 100,000 | $1.62 | $162,000 | 211,612,405 | Nov 14, 2024 |
| Frost Gamma Investments Trust | — | Purchase | 280,183 | $1.50 | $420,275 | 211,512,405 | Nov 8, 2024 |
| FROST PHILLIP MD ET AL | CEO & Chairman | Purchase | 280,183 | $1.50 | $420,275 | 211,512,405 | Nov 8, 2024 |
| FROST PHILLIP MD ET AL | CEO & Chairman | Award / Grant | 500,000 | — | — | 3,568,951 | Jul 24, 2024 |
| HSIAO JANE PH D | Vice Chairman & CTO | Award / Grant | 500,000 | — | — | 28,499,880 | Jul 24, 2024 |
| Logal Adam | Sr. Vice President, CFO | Award / Grant | 437,500 | — | — | 616,662 | Jul 24, 2024 |
| Rubin Steven D | Executive VP-Administration | Award / Grant | 437,500 | — | — | 6,625,232 | Jul 24, 2024 |
| Zerhouni Elias A. | Vice Chairman and President | Award / Grant | 500,000 | — | — | 589,600 | Jul 24, 2024 |
| Nabel Gary J. | Chief Innovation Officer | Award / Grant | 437,500 | — | — | 700,579 | Jul 24, 2024 |
| Frost Gamma Investments Trust | — | Purchase | 770 | $1.27 | $978 | 211,232,222 | May 23, 2024 |
| Frost Gamma Investments Trust | — | Purchase | 163,997 | $1.29 | $211,556 | 211,132,222 | May 17, 2024 |
| Frost Gamma Investments Trust | — | Purchase | 500,000 | $0.87 | $435,000 | 210,968,225 | Mar 18, 2024 |
| FROST PHILLIP MD ET AL | CEO & Chairman | Purchase | 500,000 | $0.89 | $445,000 | 210,468,225 | Mar 14, 2024 |
| Frost Gamma Investments Trust | — | Purchase | 500,000 | $0.93 | $465,000 | 209,968,225 | Mar 13, 2024 |
| Frost Gamma Investments Trust | — | Purchase | 600,000 | $0.93 | $558,000 | 209,468,225 | Mar 12, 2024 |
| FROST PHILLIP MD ET AL | CEO & Chairman | Purchase | 500,000 | $0.99 | $495,000 | 208,868,225 | Feb 28, 2024 |
| FROST PHILLIP MD ET AL | CEO & Chairman | Purchase | 1,000,000 | $0.99 | $990,000 | 208,368,225 | Feb 21, 2024 |
| Frost Gamma Investments Trust | — | Purchase | 1,500,000 | $0.98 | $1,470,000 | 207,368,225 | Feb 7, 2024 |
| KRASNO RICHARD M | — | Purchase | 30,000 | $0.99 | $29,700 | 103,333 | Jan 29, 2024 |
| Frost Gamma Investments Trust | — | Purchase | 500,000 | $0.98 | $490,000 | 205,868,225 | Jan 19, 2024 |
| FROST PHILLIP MD ET AL | CEO & Chairman | Purchase | 400,000 | $0.97 | $388,000 | 205,368,225 | Jan 18, 2024 |
| HSIAO JANE PH D | Vice Chairman & CTO | Purchase | 150,000 | $0.95 | $142,500 | 27,999,880 | Jan 17, 2024 |
| Frost Gamma Investments Trust | — | Purchase | 1,000,000 | $0.95 | $950,000 | 204,968,225 | Jan 16, 2024 |
| Frost Gamma Investments Trust | — | Purchase | 511,531 | $0.94 | $480,839 | 203,968,225 | Jan 11, 2024 |
| Nabel Gary J. | Chief Innovation Officer | Purchase | 108,695 | $0.93 | $101,086 | 351,442 | Jan 8, 2024 |
| HSIAO JANE PH D | Vice Chairman & CTO | Purchase | 150,010 | $0.87 | $130,509 | 27,849,880 | Jan 5, 2024 |
| Frost Gamma Investments Trust | — | Purchase | 1,500,000 | $0.90 | $1,350,000 | 203,456,694 | Jan 5, 2024 |
| Zerhouni Elias A. | Vice Chairman and President | Purchase | 400,000 | $0.94 | $376,000 | 20,327,814 | Jan 5, 2024 |
| PAGANELLI JOHN A | — | Purchase | 25,000 | $0.88 | $22,000 | 384,340 | Jan 5, 2024 |
| Rubin Steven D | Executive VP-Administration | Purchase | 10,000 | $0.87 | $8,700 | 6,187,732 | Jan 5, 2024 |